| dc.contributor.advisor | Grubhoffer, Libor | |
| dc.contributor.author | Selinger, Martin | |
| dc.date.accessioned | 2024-03-12T08:15:39Z | |
| dc.date.available | 2024-03-12T08:15:39Z | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2019-12-19 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/42890 | |
| dc.description.abstract | The proposed thesis focuses on the description of flavivirus-host
interactions in case of tick-borne encephalitis virus (TBEV) and Zika virus
(ZIKV). In more detail, the TBEV-induced host responses in human cells
of neural origin and interferon-mediated protection were described
together with the identification of a new phenomenon of TBEV-induced
host transcriptional and translational shut-off. In addition, virus-derived
molecules with hypothetical immunomodulatory characteristics, TuORF
and ZIKV sfRNA, were analysed for their presence and possible function
during the infection. | cze |
| dc.format | 186 | |
| dc.format | 186 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | flaviviruses | cze |
| dc.subject | tick-borne encephalitis virus | cze |
| dc.subject | Zika virus | cze |
| dc.subject | host response | cze |
| dc.subject | neural cells | cze |
| dc.subject | interferon | cze |
| dc.subject | flaviviruses | eng |
| dc.subject | tick-borne encephalitis virus | eng |
| dc.subject | Zika virus | eng |
| dc.subject | host response | eng |
| dc.subject | neural cells | eng |
| dc.subject | interferon | eng |
| dc.title | Molecular Factors of Cell Antiviral Immunity | cze |
| dc.title.alternative | Molecular Factors of Cell Antiviral Immunity | eng |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 35924 | |
| dc.description.abstract-translated | The proposed thesis focuses on the description of flavivirus-host
interactions in case of tick-borne encephalitis virus (TBEV) and Zika virus
(ZIKV). In more detail, the TBEV-induced host responses in human cells
of neural origin and interferon-mediated protection were described
together with the identification of a new phenomenon of TBEV-induced
host transcriptional and translational shut-off. In addition, virus-derived
molecules with hypothetical immunomodulatory characteristics, TuORF
and ZIKV sfRNA, were analysed for their presence and possible function
during the infection. | eng |
| dc.date.accepted | 2020-03-10 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Molekulární a buněčná biologie a genetika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Molekulární a buněčná biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Hirsch, Ivan | |
| dc.contributor.referee | Nuttall, Pat | |
| dc.contributor.referee | Šenigl, Filip | |
