• Catalase and Ascorbate Peroxidase in Euglenozoan Protists 

      Skodova-Sverakova, Ingrid; Zahonova, Kristina; Buckova, Barbora; Fussy, Zoltan; Yurchenko, Vyacheslav; Lukeš, Julius (MDPI AG, 2020)
      In this work, we studied the biochemical properties and evolutionary histories of catalase (CAT) and ascorbate peroxidase (APX), two central enzymes of reactive oxygen species detoxification, across the highly diverse clade ...
    • The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import 

      Kaurov, Iosif; Vancová, Marie; Schimanski, Bernd; Cadena, Lawrence Rudy; Heller, Jiri; Bílý, Tomáš; Potesil, David; Eichenberger, Claudia; Bruce, Hannah; Oeljeklaus, Silke; Warscheid, Bettina; Zdrahal, Zbynek; Schneider, Andre; Lukeš, Julius; Hashimi, Mir Mohamod Hassan (Cell Press, 2018)
      The mitochondrial contact site and cristae organization system (MICOS) is a multiprotein complex responsible for cristae formation. Even though cristae are found in all mitochondria capable of oxidative phosphorylation, ...
    • Fancy a gene? A surprisingly complex evolutionary history of peroxiredoxins. 

      Zíková, Alena; Oborník, Miroslav; Lukeš, Julius (Shared Science Publishers, 2015)
      While the phylum Apicomplexa includes “only” several thousand described species of obligatory parasites of animals, it may in fact be the most specious group of parasitic protists with over a million species [1]. The best ...
    • Malleable Mitochondrion of Trypanosoma brucei 

      Verner, Zdeněk; Basu, Somsuvro; Benz, Corinna; Dixit, Sameer; Dobáková, Eva; Faktorová, Drahomíra; Hashimi, Mir Mohamod Hassan; Horáková, Eva; Huang, Zhenqiu; Paris, Zdeněk; Peña-Diaz, Priscila; Ridlon, Lucie; Týč, Jiří; Wildridge, David; Zíková, Alena; Lukeš, Julius (Elsevier Sc., 2015)
      The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of mitochondrial biology ...
    • A Novel Bunyavirus-Like Virus of Trypanosomatid Protist Parasites 

      Akopyants, Natalia S.; Lye, Lon-Fye; Dobson, Deborah E.; Lukeš, Julius; Beverlye, Stephen M. (American Society for Microbiology, 2016)
    • Unexpectedly Streamlined Mitochondrial Genome of the Euglenozoan Euglena gracilis 

      Dobáková, Eva; Flegontov, Pavel; Skalický, Tomáš; Lukeš, Julius (Oxford University Press, 2015)
      In this study, we describe the mitochondrial genome of the excavate flagellate Euglena gracilis. Its gene complement is reduced as compared with the well-studied sister groups Diplonemea and Kinetoplastea.We have identified ...
    • Wild chimpanzees are infected by Trypanosoma brucei 

      Jirků, Milan; Votýpka, Jan; Petrželková, Klára J.; Jirků-Pomajbíková, Kateřina; Kriegová, Eva; Vodička, Roman; Lankester, Felix; Leendertz, Siv Aina J.; Wittig, Roman M.; Boesch, Christophe; Modrý, David; Ayala, Francisco J.; Leendertz, Fabian H.; Lukeš, Julius (Elsevier Science BV, 2015)
      sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples. In present work, we established a diagnostic ITS1-based PCR assay that allows detection ...