| dc.contributor.advisor | Zachleder, Vilém | |
| dc.contributor.author | Hlavová, Monika | |
| dc.date.accessioned | 2021-12-06T13:39:23Z | |
| dc.date.available | 2021-12-06T13:39:23Z | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-05-30 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/23678 | |
| dc.description.abstract | V tejto práci bol sledovaný účinok FdUrd, zeocínu, kofeínu a ich kombinácie na bunkový cyklus zelených rias Chlamydomonas reinhardtii a Scenedesmus quadricauda a tiež reakcia oboch modelových organizmov na poškodenie DNA. FdUrd aj zeocín sposobili poškodenie DNA, ktoré viedlo k zastaveniu bunkového cyklu oboch druhov rias. Naopak, kofeín čiastočne prekonal zastavenie bunkového cyklu v G2 fáze sposobené zeocínom. Pre identifikáciu mechanizmu kontrolujúceho reakciu na poškodenie DNA bola sledovaná proteínová hladina troch kľúčových regulátorov bunkového cyklu - CdkA, CdkB a Wee1 kináz. | cze |
| dc.format | 106 s. | |
| dc.format | 106 s. | |
| dc.language.iso | sk | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | bunkový cyklus | cze |
| dc.subject | poškodenie DNA | cze |
| dc.subject | zeocín | cze |
| dc.subject | kofeín | cze |
| dc.subject | FdUrd | cze |
| dc.subject | Chlamydomonas reinhardtii | cze |
| dc.subject | Scenedesmus quadricauda | cze |
| dc.subject | Wee1 | cze |
| dc.subject | DNA damage | eng |
| dc.subject | zaocin | eng |
| dc.subject | caffeine | eng |
| dc.subject | FdUrd | eng |
| dc.subject | Chlamydomonas reinhardtii | eng |
| dc.subject | Scenedesmus quadricauda | eng |
| dc.subject | Wee1 | eng |
| dc.title | Reakcia na poškodenie DNA v zelených riasach Chlamydomonas reinhardtii a Scenedesmus quadricauda | cze |
| dc.title.alternative | DNA damage response in green algae Chlamydomonas reinhardtii and Scenedesmus quadricauda | eng |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 5084 | |
| dc.description.abstract-translated | The effect of FdUrd, zeocin, caffeine and their combination on the cell cycle of green algae Chlamydomonas reinhardtii and Scenedesmus quadricauda and response of these model organisms to DNA damage were studied. Both, FdUrd and zeocin, caused DNA damage that led to cell cycle arrest in these algae. In contrast, caffeine partially abolished G2 phase block imposed by zeocin. Protein levels of three crucial cell cycle regulators - CdkA, CdkB and Wee1 kinases were measured to identify mechanisms controlling reaction to DNA damage. | eng |
| dc.date.accepted | 2011-06-17 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Molekulární a buněčná biologie a genetika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Molekulární a buněčná biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Binarová, Pavla | |
| dc.contributor.referee | Ševčovičová, Andrea | |
