| dc.contributor.author | Palus, Martin | |
| dc.date.accessioned | 2021-12-06T14:19:49Z | |
| dc.date.available | 2021-12-06T14:19:49Z | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-06-10 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/24818 | |
| dc.format | 17 | |
| dc.format | 17 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | tick-borne encephalitis | eng |
| dc.subject | recombinant congenic mouse strains | eng |
| dc.subject | neuroinflammation | eng |
| dc.title | Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response
and inflammatory reaction in the central nervous system | cze |
| dc.title.alternative | Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response
and inflammatory reaction in the central nervous system | eng |
| dc.type | rigorózní práce | cze |
| dc.identifier.stag | 43976 | |
| dc.description.abstract-translated | To address the underlying factors involved in development of tick-borne encephalitis (TBE) we developed an animal model of TBE based on BALB/c-c-STS/A (CcS/Dem) recombinant congenic mouse strains showing different severities of the infection in relation to the host genetic background. TBE virus growth, neutralizing antibody response, key cytokine and chemokine mRNA production and changes in mRNA levels of cell surface markers of immunocompetent cells in brain were measured in mice with different susceptibilities to TBE virus infection. Generated data indicate that the genetic control is an important factor influencing the clinical course of TBE. | eng |
| dc.date.accepted | 2015-06-29 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Klinická biologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | RNDr. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
