| dc.contributor.advisor | Bruce, Alexander William | |
| dc.contributor.author | Thamodaran, Vasanth | |
| dc.date.accessioned | 2021-12-08T12:31:46Z | |
| dc.date.available | 2021-12-08T12:31:46Z | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-10-10 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/33621 | |
| dc.description.abstract | ANNOTATION
This thesis describes the role of p38 mitogen activated kinases alpha/beta, also referred to as Mapk14/11 (p38-Mapk14/11), in regulating primitive endoderm (PrE) cell-fate and its sensitivity towards exogenously supplemented amino acids during mouse preimplantation embryo development. This study utilizing various pharmacological inhibitors, gene transcript over-expression and immunofluorescence assisted confocal microscopy imaging, has revealed a novel and pivotal role p38-Mapk14/11 in promoting germane maturation of the blastocyst stage inner cell mass (ICM)into the defined epiblast (EPI) and PrE and its potential requirement under amino acid deprived conditions. | cze |
| dc.format | 195p. (34 3373 characters) | |
| dc.format | 195p. (34 3373 characters) | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.title | The role of p38-Mapk14/11 as an enabler of primitive endoderm (PrE) maturation and as a sensor of metabolism during mouse preimplantation embryo development | cze |
| dc.title.alternative | The role of p38-Mapk14/11 as an enabler of primitive endoderm (PrE) maturation and as a sensor of metabolism during mouse preimplantation embryo development | eng |
| dc.title.alternative | p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development | cze |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 26803 | |
| dc.description.abstract-translated | ANNOTATION
This thesis describes the role of p38 mitogen activated kinases alpha/beta, also referred to as Mapk14/11 (p38-Mapk14/11), in regulating primitive endoderm (PrE) cell-fate and its sensitivity towards exogenously supplemented amino acids during mouse preimplantation embryo development. This study utilizing various pharmacological inhibitors, gene transcript over-expression and immunofluorescence assisted confocal microscopy imaging, has revealed a novel and pivotal role p38-Mapk14/11 in promoting germane maturation of the blastocyst stage inner cell mass (ICM)into the defined epiblast (EPI) and PrE and its potential requirement under amino acid deprived conditions. | eng |
| dc.date.accepted | 2016-12-12 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Molekulární a buněčná biologie a genetika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Molekulární a buněčná biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Plusa, Berenika | |
| dc.contributor.referee | Susor, Andrej | |
