The Interplay Between the Notch Signaling Pathway and Cellular Metabolism

Slaninová, Věra

dc.contributor.advisor	Bruce, Alena
dc.contributor.author	Slaninová, Věra
dc.date.accessioned	2021-12-08T12:55:01Z
dc.date.available	2021-12-08T12:55:01Z
dc.date.issued	2017
dc.date.submitted	2016-12-17
dc.identifier.uri	https://dspace.jcu.cz/handle/20.500.14390/33846
dc.description.abstract	We identified four metabolic genes as direct targets of Notch signaling pathway both in vitro and in vivo and investigated the hypothesis that Notch directed metabolic changes support the growth of the imaginal wing dics. Vice versa, we observed the influence of metabolic changes on the activity of Notch signaling pathway and we identified Sirt1 as a metabolic sensor for the Notch pathway that helps to elicit an efficient response to Notch signal, in a metabolism sensitive manner.	cze
dc.format	127
dc.format	127
dc.language.iso	eng
dc.publisher	Jihočeská univerzita	cze
dc.rights	Bez omezení
dc.subject	Notch	cze
dc.subject	metabolism	cze
dc.subject	growth	cze
dc.subject	metabolic sensors	cze
dc.subject	sirt1	cze
dc.subject	Notch	eng
dc.subject	metabolism	eng
dc.subject	growth	eng
dc.subject	metabolic sensors	eng
dc.subject	sirt1	eng
dc.title	The Interplay Between the Notch Signaling Pathway and Cellular Metabolism	cze
dc.title.alternative	The Interplay Between the Notch Signaling Pathway and Cellular Metabolism	eng
dc.type	disertační práce	cze
dc.identifier.stag	30999
dc.description.abstract-translated	We identified four metabolic genes as direct targets of Notch signaling pathway both in vitro and in vivo and investigated the hypothesis that Notch directed metabolic changes support the growth of the imaginal wing dics. Vice versa, we observed the influence of metabolic changes on the activity of Notch signaling pathway and we identified Sirt1 as a metabolic sensor for the Notch pathway that helps to elicit an efficient response to Notch signal, in a metabolism sensitive manner.	eng
dc.date.accepted	2017-01-19
dc.description.department	Přírodovědecká fakulta	cze
dc.thesis.degree-discipline	Molekulární a buněčná biologie a genetika	cze
dc.thesis.degree-grantor	Jihočeská univerzita. Přírodovědecká fakulta	cze
dc.thesis.degree-name	Ph.D.
dc.thesis.degree-program	Molekulární a buněčná biologie	cze
dc.description.grade	Dokončená práce s úspěšnou obhajobou	cze
dc.contributor.referee	Dijane, Alexandre
dc.contributor.referee	Macůrková, Marie