| dc.contributor.advisor | Paris, Zdeněk | |
| dc.contributor.author | Kulkarni, Sneha Sunil | |
| dc.date.accessioned | 2024-03-12T11:37:54Z | |
| dc.date.available | 2024-03-12T11:37:54Z | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-01 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/44922 | |
| dc.description.abstract | This study analyzes the queuosine (Q) tRNA modification and the enzyme responsible for
Q formation, the tRNA guanine transglycosylase (TGT), in the parasitic protist
<i>Trypanosoma brucei</i>. We describe the interdependence of Q modification and tRNA
subcellular trafficking, and how these two factors regulate codon biased translation. The effect of Q on translation has serious implications in the virulence of the parasite inside the mammalian host. | cze |
| dc.format | 156 p | |
| dc.format | 156 p | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Práce bude přístupná od 01.10.2024 | |
| dc.subject | Queuosine | cze |
| dc.subject | tRNA guanine transglycosylase | cze |
| dc.subject | tRNA modifications | cze |
| dc.subject | tRNA traficking | cze |
| dc.subject | mitochondria | cze |
| dc.subject | synonymous codon usage | cze |
| dc.subject | Queuosine | eng |
| dc.subject | tRNA guanine transglycosylase | eng |
| dc.subject | tRNA modifications | eng |
| dc.subject | tRNA traficking | eng |
| dc.subject | mitochondria | eng |
| dc.subject | synonymous codon usage | eng |
| dc.title | Role of queuosine tRNA modification in the parasitic protist <i>Trypanosoma brucei</i> | cze |
| dc.title.alternative | Role of queuosine tRNA modification in the parasitic protist <i>Trypanosoma brucei</i> | eng |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 45932 | |
| dc.description.abstract-translated | This study analyzes the queuosine (Q) tRNA modification and the enzyme responsible for
Q formation, the tRNA guanine transglycosylase (TGT), in the parasitic protist
<i>Trypanosoma brucei</i>. We describe the interdependence of Q modification and tRNA
subcellular trafficking, and how these two factors regulate codon biased translation. The effect of Q on translation has serious implications in the virulence of the parasite inside the mammalian host. | eng |
| dc.date.accepted | 2021-10-01 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Molekulární a buněčná biologie a genetika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Molekulární a buněčná biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Kelly, Vincent | |
| dc.contributor.referee | Siegel, Nicolai | |
