| dc.contributor.advisor | Hrouzek, Pavel | |
| dc.contributor.author | Hájek, Jan | |
| dc.date.accessioned | 2025-03-06T08:06:34Z | |
| dc.date.available | 2025-03-06T08:06:34Z | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2021-11-25 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/46270 | |
| dc.format | 170 | |
| dc.format | 170 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | cyanobacteria | eng |
| dc.subject | cyclic lipopeptide | eng |
| dc.subject | bioactivity | eng |
| dc.title | Structural variability of cyclic cyanobacterial lipopeptides: their biosynthesis and features affecting their bioactivity | cze |
| dc.title.alternative | Structural variability of cyclic cyanobacterial lipopeptides: their biosynthesis and features affecting their bioactivity | eng |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 39926 | |
| dc.description.abstract-translated | This thesis is devoted to the diversity of cyanobacterial cyclic lipopeptides and their bioactivity. Special class of cyclic cyanobacterial lipopeptides puwainaphycins and minutissamides was studied in terms of their structural diversity, biosynthesis and structure-activity relationship. Chemical diversity of observed variants in cyanobacterial strains was correlated with the genetic background for their biosynthesis from which the probable cores of biosynthesis were inferred. Biological activity (mainly the cytotoxicity and anti-fungal activity) of major natural puwainaphycin and minutissamide variants was studied in detail. Finally, semi-synthetic puwainaphycin and minutissamide variants were prepared in order to study the relationship between distinct functional moieties and their effect on the bioactivity of the lipopeptide. | eng |
| dc.date.accepted | 2022-01-13 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Molekulární a buněčná biologie a genetika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Molekulární a buněčná biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Leao, Pedro | |
| dc.contributor.referee | Luesch, Hendrik | |
