| dc.contributor.advisor | Fiala, Ivan | |
| dc.contributor.author | Kyslík, Jiří | |
| dc.date.accessioned | 2025-03-06T08:58:16Z | |
| dc.date.available | 2025-03-06T08:58:16Z | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-04-29 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/46826 | |
| dc.format | 120 s. | |
| dc.format | 120 s. | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | Myxozoa | eng |
| dc.subject | taxonomically-restricted genes | eng |
| dc.subject | minicollagens | eng |
| dc.subject | development | eng |
| dc.subject | polar capsule | eng |
| dc.title | Bioinformatická a funkční charakterizace taxonomicky omezených genů | cze |
| dc.title.alternative | Bioinformatics and functional characterization of
taxonomically-restricted genes in Myxozoa | eng |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 49417 | |
| dc.description.abstract-translated | Evolutionary dynamics, generating novel phenotypic traits, embody an essential route to either lineage-specific adaptations or to the creation of endless forms in organisms. Understanding the evolution of such ultimate novelties requires the study of the origin and the role of the functional units in generating unique traits, which represent the taxon-specific genes (TRGs). Myxozoa, the endoparasitic cnidarians, have become a suitable model for the study of evolutionary innovations, with their example of single-celled novelty: polar capsules. This uniquelly evolved structure within the spore stage represents a lineage-specific analogy of cnidarian stinging cells (nematocyst). In Cnidaria, nematocysts contain several uniquely emerged genes, rendering the assembly of this complex structure. The prominent fraction represents minicollagens, extremely shortened structural peptides forming the wall and tubule during the nematocyst development. Unlike in Cnidaria, the role of TRGs such as minicollagens in myxozoan development is unknown. The thesis describes the evolution and functional characterization of minicollagens in Myxozoa. Using the bioinformatics and molecular approaches, we explored the diversity and genomic organization and comprehensively characterized minicollagen gene expressions during myxospore development and localization of minicollagens in the polar capsule. | eng |
| dc.date.accepted | 2022-06-08 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Parazitologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Atkinson, Stephen | |
| dc.contributor.referee | Lotan, Tamar | |
| dc.description.defence | <p>Obhajoba proběhla v hybridní formě. Školitel představil uchazeče a shrnul význam jeho předkládané práce. Uchazeč seznámil komisi s výsledky své dizertační práce. Předsedkyně komise přečetla posudek nepřítomné oponentky. Přítomný oponent (online) seznámil komisi se svým posudkem. Uchazeč odpověděl na otázky oponenta. Další diskuse se týkala plánů na další postup ve výzkumu.</p> | cze |
