| dc.contributor.advisor | Hashimi, Hassan | |
| dc.contributor.author | Ridlon, Lucie | |
| dc.date.accessioned | 2021-12-06T13:09:10Z | |
| dc.date.available | 2021-12-06T13:09:10Z | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-04-30 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/23489 | |
| dc.description.abstract | This thesis concerns a putative protein complex called the Mitochondrial Binding Complex 1 (MRB1),
subunits of which have essential functions in the RNA metabolism of both procyclic and bloodstream forms of T.
brucei. The focus of this study is on one of the subunits, called MRB3010. It was shown that this subunit of
MRB1 complex is essential in both stages of T. brucei and the MRB3010 silencing affects the maxicircle encoded
edited and pre-edited transcripts. However, the downregulation of this protein appears not to affect the assembly
of other putative subunits into MRB1. | cze |
| dc.format | 53 | |
| dc.format | 53 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.title | Functional analysis of subunit MRB3010 of the mitochondrial binding complex 1 in <i>Trypanosoma brucei</i>. | cze |
| dc.title.alternative | Functional analysis of subunit MRB3010 of the mitochondrial binding complex 1 in <i>Trypanosoma brucei</i>. | eng |
| dc.type | diplomová práce | cze |
| dc.identifier.stag | 14215 | |
| dc.description.abstract-translated | This thesis concerns a putative protein complex called the Mitochondrial Binding Complex 1 (MRB1),
subunits of which have essential functions in the RNA metabolism of both procyclic and bloodstream forms of T.
brucei. The focus of this study is on one of the subunits, called MRB3010. It was shown that this subunit of
MRB1 complex is essential in both stages of T. brucei and the MRB3010 silencing affects the maxicircle encoded
edited and pre-edited transcripts. However, the downregulation of this protein appears not to affect the assembly
of other putative subunits into MRB1. | eng |
| dc.date.accepted | 2010-05-25 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Experimentální biologie - specializace Buněčná a vývojová biologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Mgr. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Panicucci Zíková, Alena | |
| dc.contributor.referee | Staněk, David | |
