| dc.contributor.advisor | Lukeš, Julius | |
| dc.contributor.author | Basu, Somsuvro | |
| dc.date.accessioned | 2021-12-06T14:04:57Z | |
| dc.date.available | 2021-12-06T14:04:57Z | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-09-01 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/24401 | |
| dc.description.abstract | This thesis highlights a divergent mitochondrial intermembrane assembly pathway in
the parasitic protist Trypanosoma brucei. A comparative genomic study reveals the
connection of Erv1 with the cytosolic iron-sulfur protein assembly (CIA) pathway in
trypanosomatids. Further, the CIA machinery of T. brucei has been described using
RNAi interference and other biochemical and complementation assays. Finally, part
of the divergent CIA machinery has been identified in the human intestinal pathogen
Giardia intestinalis by means of complementation assays in T. brucei. | cze |
| dc.format | 141 | |
| dc.format | 141 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | CIA pathway | cze |
| dc.subject | Fe/S cluster | cze |
| dc.subject | Trypanosoma brucei | cze |
| dc.subject | MIA pathway | cze |
| dc.subject | RNAi | cze |
| dc.subject | CIA pathway | eng |
| dc.subject | Fe/S cluster | eng |
| dc.subject | Trypanosoma brucei | eng |
| dc.subject | MIA pathway | eng |
| dc.subject | RNAi | eng |
| dc.title | Erv1 associated mitochondrial import-export pathway and the cytosolic iron-sulfur protein assembly machinery in Trypanosoma brucei | cze |
| dc.title.alternative | Erv1 associated mitochondrial import-export pathway and the cytosolic iron-sulfur protein assembly machinery in Trypanosoma brucei | eng |
| dc.type | disertační práce | cze |
| dc.identifier.stag | 19944 | |
| dc.description.abstract-translated | This thesis highlights a divergent mitochondrial intermembrane assembly pathway in
the parasitic protist Trypanosoma brucei. A comparative genomic study reveals the
connection of Erv1 with the cytosolic iron-sulfur protein assembly (CIA) pathway in
trypanosomatids. Further, the CIA machinery of T. brucei has been described using
RNAi interference and other biochemical and complementation assays. Finally, part
of the divergent CIA machinery has been identified in the human intestinal pathogen
Giardia intestinalis by means of complementation assays in T. brucei. | eng |
| dc.date.accepted | 2014-09-18 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Molekulární a buněčná biologie a genetika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Ph.D. | |
| dc.thesis.degree-program | Molekulární a buněčná biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Doležal, Pavel | |
| dc.contributor.referee | Mühlenhoff, Ulrich | |
| dc.contributor.referee | Smith, Terry K. | |
