Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of <i>Trypanosoma brucei</i> and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
Abstrakt
The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.