Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of <i>Trypanosoma brucei</i> and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase

Mittermayr, Martina

dc.contributor.advisor	Panicucci Zíková, Alena
dc.contributor.author	Mittermayr, Martina
dc.date.accessioned	2021-12-06T13:41:48Z
dc.date.available	2021-12-06T13:41:48Z
dc.date.issued	2012
dc.date.submitted	2012-05-18
dc.identifier.uri	https://dspace.jcu.cz/handle/20.500.14390/23892
dc.description.abstract	The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.	cze
dc.format	40
dc.format	40
dc.language.iso	eng
dc.publisher	Jihočeská univerzita	cze
dc.rights	Bez omezení
dc.subject	Trypanosoma brucei	cze
dc.subject	HAT	cze
dc.subject	Human African Trypanosomiasis	cze
dc.subject	RNAi	cze
dc.subject	HGXPRT	cze
dc.subject	acyclic nucleoside phosphonates	cze
dc.subject	ANP	cze
dc.subject	purine salvage pathway	cze
dc.subject	AlamarBlue	cze
dc.subject	bloodstream T.brucei	cze
dc.subject	Trypanosoma brucei	eng
dc.subject	HAT	eng
dc.subject	Human African Trypanosomiasis	eng
dc.subject	RNAi	eng
dc.subject	HGXPRT	eng
dc.subject	acyclic nucleoside phosphonates	eng
dc.subject	ANP	eng
dc.subject	purine salvage pathway	eng
dc.subject	AlamarBlue	eng
dc.subject	bloodstream T.brucei	eng
dc.title	Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of <i>Trypanosoma brucei</i> and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase	cze
dc.title.alternative	Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of <i>Trypanosoma brucei</i> and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase	eng
dc.type	bakalářská práce	cze
dc.identifier.stag	25209
dc.description.abstract-translated	The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.	eng
dc.date.accepted	2012-06-18
dc.description.department	Přírodovědecká fakulta	cze
dc.thesis.degree-discipline	Biological Chemistry	cze
dc.thesis.degree-grantor	Jihočeská univerzita. Přírodovědecká fakulta	cze
dc.thesis.degree-name	Bc.
dc.thesis.degree-program	Biochemistry	cze
dc.description.grade	Dokončená práce s úspěšnou obhajobou	cze
dc.contributor.referee	Tomčala, Aleš