| dc.contributor.advisor | Kopáček, Petr | |
| dc.contributor.author | Hartmann, David | |
| dc.date.accessioned | 2021-12-06T14:06:03Z | |
| dc.date.available | 2021-12-06T14:06:03Z | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2013-12-13 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/24521 | |
| dc.format | 47 s. | |
| dc.format | 47 s. | |
| dc.language.iso | cze | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | Faktor C | cze |
| dc.subject | klíště | cze |
| dc.subject | ixodes ricinus | cze |
| dc.subject | koagulace hemolymfy | cze |
| dc.subject | Factor C | eng |
| dc.subject | tick | eng |
| dc.subject | Ixodes ricinus | eng |
| dc.subject | hemolymph clotting | eng |
| dc.title | Charakterizace a funkce faktoru C z klíštěte <i>Ixodes ricinus</i> | cze |
| dc.title.alternative | Characterization and function of Factor C from the tick <i>Ixodes ricinus</i> | eng |
| dc.type | diplomová práce | cze |
| dc.identifier.stag | 30500 | |
| dc.description.abstract-translated | Factor C is a multi-domain serine protease which recognizes Gram-negative bacteria via binding to lipopolysaccharides and triggers hemolymph clotting cascade in the horseshoe crab. A closely related molecule was also found to be present in the genome of the tick Ixodes scapularis. In this work, the full sequence of Factor C ortholog from Ixodes ricinus (IrFC) was determined. IrFC is mainly expressed in tick hemocytes and the heavy chain of the activated molecules is present in tick hemolymph as confirmed by Western blotting with antibodies raised against recombinant fragments of IrFC. The function of the IrFC in tick innate immunity was assessed using its silencing by RNA interference. | eng |
| dc.date.accepted | 2014-01-23 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Klinická biologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Mgr. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Hajdušek, Ondřej | |
| dc.contributor.referee | Hyršl, Pavel | |
