| dc.contributor.advisor | Lieskovská, Jaroslava | |
| dc.contributor.author | Neradová, Hana | |
| dc.date.accessioned | 2021-12-06T14:06:22Z | |
| dc.date.available | 2021-12-06T14:06:22Z | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-04-25 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/24546 | |
| dc.description.abstract | Klíštěcí sliny obsahují mnoho molekul s antihemostatickými a imunomodulačními funkcemi. Cílem této práce bylo otestovat vliv cystatinů CPI1 a CPI2 klíštěte I.ricius a sialostatinů L a L2 klíštěte I.scapularis na maturaci dendritických buněk derivovaných z kostní dřeně indukovanou TLR ligandy. | cze |
| dc.format | 48 s. | |
| dc.format | 48 s. | |
| dc.language.iso | cze | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | dendritické buňky | cze |
| dc.subject | TLR-receptory | cze |
| dc.subject | TLR-ligandy | cze |
| dc.subject | cystatiny | cze |
| dc.subject | sialostatin L | cze |
| dc.subject | sialostatin L2 | cze |
| dc.subject | LPS | cze |
| dc.subject | LTA | cze |
| dc.subject | imiquimod | cze |
| dc.subject | POLY I:C | cze |
| dc.subject | dendritic cell | eng |
| dc.subject | TLR-receptor | eng |
| dc.subject | LPS | eng |
| dc.subject | LTA | eng |
| dc.subject | imiquimod | eng |
| dc.subject | POLY I:C | eng |
| dc.subject | cystatins | eng |
| dc.subject | sialostatin L | eng |
| dc.subject | sialostatin L2 | eng |
| dc.title | Vliv klíštěcích cystatinů na TLR - indukovanou maturaci myeloidních dendritických buněk | cze |
| dc.title.alternative | The effect of tick cystatins on TLR - induced maturation
of myeloid dendritic cells | eng |
| dc.type | diplomová práce | cze |
| dc.identifier.stag | 32355 | |
| dc.description.abstract-translated | Tick saliva contains a lot of molecules with antihemostatic and immunosupressive
effects.The goal of this thesis is to test the effects of tick salivary cystatins from I.ricinus and
I.scapularis on TLR - induced maturation of bone-marrow derived dendritic cells and
production of chosen cytokines. Over all, the supressive effect of tick cystatins was observed
in relation to TLR-induced maturation of DC. In addition, cystatins enhanced production of
IL-10 and attenuated induction of IL-12 cytokines. | eng |
| dc.date.accepted | 2014-05-30 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Klinická biologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Mgr. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Chmelař, Jindřich | |
| dc.contributor.referee | Urbanová, Veronika | |
