| dc.contributor.advisor | Ženka, Jan | |
| dc.contributor.author | Masáková, Kamila | |
| dc.date.accessioned | 2022-03-08T14:24:36Z | |
| dc.date.available | 2022-03-08T14:24:36Z | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-04-10 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/38630 | |
| dc.format | 59 s. (82 725 znaků) | |
| dc.format | 59 s. (82 725 znaků) | |
| dc.language.iso | cze | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | nádorová onemocnění | cze |
| dc.subject | imunoterapie | cze |
| dc.subject | TLR agonisté | cze |
| dc.subject | ligandy stimulující fagocytózu | cze |
| dc.subject | nádorové mikroprostředí | cze |
| dc.subject | enzymy | cze |
| dc.subject | laktát | cze |
| dc.subject | pankreatický adenokarcinom | cze |
| dc.subject | cancer | eng |
| dc.subject | immunotherapy | eng |
| dc.subject | TLR agonists | eng |
| dc.subject | phagocytosis stimulating ligands | eng |
| dc.subject | tumor microenvironment | eng |
| dc.subject | enzymes | eng |
| dc.subject | lactate | eng |
| dc.subject | pancreatic adenocarcinoma | eng |
| dc.title | Nádorová imunoterapie založená na mechanismech vrozené imunity a studium možnosti zvýšení její účinnosti úpravou nádorového prostředí | cze |
| dc.title.alternative | Cancer immunotherapy based on mechanisms of innate immunity and the study of possibilities how to increase its effectiveness by adaptation of tumor´s environment | eng |
| dc.type | diplomová práce | cze |
| dc.identifier.stag | 50111 | |
| dc.description.abstract-translated | The aim of this thesis was to study how to increase effectiveness of cancer immunotherapy based on synergy of compounds stimulating phagocytosis and TLR agonist. Tumor microenvironment was modified by enzymes, which catalised conversion of lactate to pyruvate or acetate. It was monitored effect of enzymes on tumor size, survival of experimental mice and cytotoxicity on tumor cells. | eng |
| dc.date.accepted | 2018-05-22 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Klinická biologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Mgr. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Chmelař, Jindřich | |
| dc.contributor.referee | Žampachová, Eva | |
