| dc.contributor.advisor | Hashimi, Hassan | |
| dc.contributor.author | Cadena, Lawrence Rudy | |
| dc.date.accessioned | 2025-03-06T08:06:19Z | |
| dc.date.available | 2025-03-06T08:06:19Z | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2021-12-08 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/46250 | |
| dc.description.abstract | The acquisition of mitochondria from an endosymbiont closely related to extant alphaproteobacteria occurred prior to the divergence of modern eukaryotes. Since then, diverse eukaryotes have not only developed a number of different mechanisms to adapt to their environment regarding growth and proliferation, but perpetuated certain traits that have persisted for eons. This thesis postulates an ancestral mechanism for cristae development in mitochondria involving interplay between two cristae shaping protein complexes, the Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase, that has remained conserved throughout eukaryotic diversification for over 2 billion years. | cze |
| dc.format | 53p. | |
| dc.format | 53p. | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | Mitochondria | cze |
| dc.subject | MICOS | cze |
| dc.subject | ATP Synthase | cze |
| dc.subject | Trypanosoma brucei | cze |
| dc.subject | evolution | cze |
| dc.subject | protein interaction | cze |
| dc.subject | Mitochondria | eng |
| dc.subject | MICOS | eng |
| dc.subject | ATP Synthase | eng |
| dc.subject | Trypanosoma brucei | eng |
| dc.subject | evolution | eng |
| dc.subject | protein interaction | eng |
| dc.title | The Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk is a Fundamental Property of Mitochondrial Cristae | cze |
| dc.title.alternative | The Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk is a Fundamental Property of Mitochondrial Cristae | eng |
| dc.type | diplomová práce | cze |
| dc.identifier.stag | 62990 | |
| dc.description.abstract-translated | The acquisition of mitochondria from an endosymbiont closely related to extant alphaproteobacteria occurred prior to the divergence of modern eukaryotes. Since then, diverse eukaryotes have not only developed a number of different mechanisms to adapt to their environment regarding growth and proliferation, but perpetuated certain traits that have persisted for eons. This thesis postulates an ancestral mechanism for cristae development in mitochondria involving interplay between two cristae shaping protein complexes, the Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase, that has remained conserved throughout eukaryotic diversification for over 2 billion years. | eng |
| dc.date.accepted | 2022-01-20 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Experimental Biology - Molecular and Cell Biology and Genetics | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Mgr. | |
| dc.thesis.degree-program | Biology | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Ramplet, Heike | |
| dc.contributor.referee | Trnka, Jan | |
| dc.description.defence | <p>Obhajoba magisterskej diplomovej práce Bc. Rudy Lawrence Cadena, BSc.</p>
<p> </p>
<p>Obhajoba prebehla prezenčne.</p>
<p> </p>
<p>Zmeny v zložení komisie:<br />
<br />
RNDr. Alena Bruce Krejčí z dovodu nemoci neprítomná, náhradník Mgr. Lenka Chodáková, Ph.D., náhradný predseda komisie RNDr. Petr Nguyen, Ph.D. Mgr. Aleš Horák z dovodu nemoci neprítomný, ako náhradný člen komisie bol určený Mgr. Adam Bajgar, Ph.D.<br />
Oponenti Dr. Heike Ramplet a doc. Jan Trnka neboli osobne prítomní.</p>
<p> </p>
<p>Školiteľ prečítal školiteľský posudok a vyzdvihol samostatnú prácu študenta a jeho vysoké porozumenie problematiky. Taktiež vyzdvihol jeho participáciu na vedeckých publikáciach. Prácu doporučil k obhajobe.</p>
<p> </p>
<p>Študent prezentoval svoju prácu v časovom limite a odpovedal na otázky oponentov. Oponenti sa v elektronickej komunikácii vyjadrili kladne a spokojne s reakciami študenta (priložené v zložke pre študíjne oddelenie). Následne bola otvorená diskusia ostatných členov komisie a publika. Dr. Brian Panicucci: "How do the different ETC complexes assemble? Why do you see the oligomerization in Mic60?" Študent extenzívne odpovedal a potvrdil svoje znalosti o projekte.</p>
<p> </p>
<p>Obhajoba bola hodnotená 4x známkou výborne.</p> | cze |
