| dc.contributor.advisor | Paris, Zdeněk | |
| dc.contributor.author | Švábová, Monika | |
| dc.date.accessioned | 2025-03-06T08:06:21Z | |
| dc.date.available | 2025-03-06T08:06:21Z | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-04-13 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/46256 | |
| dc.format | 62 | |
| dc.format | 62 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | Leishmania mexicana | eng |
| dc.subject | translation | eng |
| dc.subject | queuosine | eng |
| dc.subject | modification | eng |
| dc.subject | ribosome profiling | eng |
| dc.subject | polysome profiling | eng |
| dc.subject | tRNA | eng |
| dc.title | The role of Q tRNA modification in codon biased translation in <i>Leishmania mexicana</i> | cze |
| dc.title.alternative | The role of Q tRNA modification in codon biased translation in <i>Leishmania mexicana</i> | eng |
| dc.type | diplomová práce | cze |
| dc.identifier.stag | 63725 | |
| dc.description.abstract-translated | The aim of the thesis was to standardize polysome profiling and ribosome profiling protocols for the parasitic protist Leishmania mexicana in order to identify the effect of Q-tRNAs in translation. In addition, we analyzed the role of queuosine (Q) t-RNA modification in the cell cycle of L. mexicana. The proteomics analysis was carried out in order to elucidate the role of Q-tRNAs in protein folding. | eng |
| dc.date.accepted | 2022-05-26 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Experimentální biologie - specializace Molekulární a buněčná biologie a genetika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Mgr. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.description.defence | <p>Obhajoba prebehla hybridnou formou.</p>
<p>Komisia v zložení: Mgr. Lenka Chodáková, Ph.D. - predseda, Mgr. Adam Bajgar, Ph.D., Mgr. Iva Mozgová, Ph.D.</p>
<p>Oponenti: prof. MSc. Vjačeslav Jurčenko, Ph.D. (online), Mgr. Michaela Fencková, Ph.D.</p>
<p>Zapisovateľ: Mgr. Lenka Chodáková, Ph.D.</p>
<p>Počet hostů: 4</p>
<p> </p>
<p>Priebeh: Mentor read his review, and is happy with Monika's results and work in the laboratory and the thesis. The results will be a part of a publication. Student presented her work in the limit.</p>
<p>Oponent prof. Jurčenko commented on Monika's thesis and concluded her review - he acknowledged her good work and was impressed by the results. He only commented on some formal mistakes which are not harmful to the overall quality of the thesis.<br />
During the discussion with student the oponent asked 4 questions which the student sufficiently answered.</p>
<p>Oponent Dr. Fencková critisized the formal aspects of the thesis and also not clear structure of the thesis. She was also not happy with the result section and English. As most of the questions were already answered during Monika's presentation, the oponent asked only additional questions and is happy with the answers.</p>
<p>The comitee acknowledged the students work and presentation of the results.</p>
<p> </p>
<p> </p>
<p> </p> | cze |
