Uptake and metabolism of valsartan and candesartan in different plants.

Zellner, Laura

dc.contributor.advisor	Himmelsbach, Markus
dc.contributor.author	Zellner, Laura
dc.date.accessioned	2026-01-06T11:55:30Z
dc.date.available	2026-01-06T11:55:30Z
dc.date.issued	2023
dc.date.submitted	2023-03-22
dc.identifier.uri	https://dspace.jcu.cz/handle/20.500.14390/48677
dc.description.abstract	Due to the nowadays extensive pollution of the environment with pharmaceuticals and personal care products, plants are exposed to a significant concentration of xenobiotics. For this reason, a growing number of scientists is focussing on the interaction between these chemicals and plants. Likewise, the present work investigates the uptake and transformation of two blood pressure lowering drugs, namely candesartan and valsartan, in several plant species by high-performance liquid chromatography hyphenated with a drift-tube ion-mobility quadrupole time-of-flight mass spectrometer.	cze
dc.format	70 p. (96 496 characters)
dc.format	70 p. (96 496 characters)
dc.language.iso	eng
dc.publisher	Jihočeská univerzita	cze
dc.rights	Bez omezení
dc.subject	environmental analysis	cze
dc.subject	plant metabolism	cze
dc.subject	pharmaceuticals	cze
dc.subject	sartans	cze
dc.subject	drift-tube ion-mobility mass spectrometry	cze
dc.subject	plant uptake	cze
dc.subject	environmental analysis	eng
dc.subject	plant metabolism	eng
dc.subject	pharmaceuticals	eng
dc.subject	sartans	eng
dc.subject	drift-tube ion-mobility mass spectrometry	eng
dc.subject	plant uptake	eng
dc.title	Uptake and metabolism of valsartan and candesartan in different plants.	cze
dc.title.alternative	Uptake and metabolism of valsartan and candesartan in different plants.	eng
dc.type	diplomová práce	cze
dc.identifier.stag	70194
dc.description.abstract-translated	Due to the nowadays extensive pollution of the environment with pharmaceuticals and personal care products, plants are exposed to a significant concentration of xenobiotics. For this reason, a growing number of scientists is focussing on the interaction between these chemicals and plants. Likewise, the present work investigates the uptake and transformation of two blood pressure lowering drugs, namely candesartan and valsartan, in several plant species by high-performance liquid chromatography hyphenated with a drift-tube ion-mobility quadrupole time-of-flight mass spectrometer.	eng
dc.date.accepted	2023-07-17
dc.description.department	Přírodovědecká fakulta	cze
dc.thesis.degree-discipline	Biological Chemistry	cze
dc.thesis.degree-grantor	Jihočeská univerzita. Přírodovědecká fakulta	cze
dc.thesis.degree-name	Mgr.
dc.thesis.degree-program	Biological Chemistry	cze
dc.description.grade	Dokončená práce s úspěšnou obhajobou	cze
dc.description.defence	<p>The student and the members of the committee were welcomed. Mrs Zellner introduced the topic - water reuse for crop irrigation and the related problems. Two molecules were studied in relation to the uptake and metabolism of chemicals from water - valsartan and candesartan. Mostly LC-MS/MS was used together with the development of new methods. After the methodology description, the results were shown. Metabolites of both drugs were identified in the samples of various plants using database search and in-house methods.</p> <p>The student then answered questions on the selection of studied drugs, their solubility, the possibility of removing them from wastewater, the methodology, the samples used, comparison of various used techniques,</p> <p>4x excellent.</p>	cze