Production and functional characterization of tick salivary protease inhibitors
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Date
Authors
Kotál, Jan
Journal Title
Journal ISSN
Volume Title
Publisher
Jihočeská univerzita
Abstract
Two cysteine and two serine protease inhibitors from a tick Ixodes ricinus saliva were
overexpressed using a prokaryotic overexpression system and refolded to their native state.
Both cysteine protease inhibitors were tested as potential antigens for an anti-tick vaccine
showing no effect on tick feeding or reproduction. Various immunological methods were
employed to test the potential immunomodulatory function of these proteins without success.