| dc.contributor.advisor | Kváč, Martin | |
| dc.contributor.author | Jalovecká, Marie | |
| dc.date.accessioned | 2021-12-06T13:07:42Z | |
| dc.date.available | 2021-12-06T13:07:42Z | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-04-30 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/23349 | |
| dc.language.iso | cze | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.title | Imunitní odpověď myší na infekci žaludečními kryptosporidiemi | cze |
| dc.title.alternative | The immune response of mice to gastric cryptosporidium infections | eng |
| dc.type | bakalářská práce | cze |
| dc.identifier.stag | 16058 | |
| dc.description.abstract-translated | The immune response in stomach mucosa during the primary infection and
re-infection of Cryptosporidium muris (TS03 and CB03) and C. andersoni
in immunocompetent BALB/c mice was observed in this study. No significant
differences in the induction of a cellular response were observed in mice infected with the two strains of C. muris. Significantly elevated migration
of T-lymphocytes (more than 1000-fold), especially CD8+ T lymphocytes, to the
stomach mucosa was described during primary infection. Moreover, the persisting
severalfold increased level of T-lymphocytes in stomach epithelium was observed
2 months after recovery from the primary cryptosporidiosis. Very low level of IFN-{γ} production in ex vivo cultures of splenocytes was recorded during the course of the primary infection (0.5 ng/ml), whereas during reinfection the concentration of IFN-{γ} rapidly increased 22-fold (10.7 ng/ml). After infection of BALB/c mice with C. andersoni LI03, migration of T-lymphocytes and production of INF-{γ} in ex vivo splenocyte primary cultures was also observed, even though this isolate of C. andersoni does not infect Mus musculus. These results imply that the CD8+ T-lymphocytes are involved in the immune response to gastric cryptosporidiosis and could play an important role in the elimination of C. muris infection in mice. | eng |
| dc.date.accepted | 2009-06-02 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Biomedicínská laboratorní technika | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Bc. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Kopecký, Jan | |
