Molecular Factors of Cell Antiviral Immunity
Abstrakt
The proposed thesis focuses on the description of flavivirus-host
interactions in case of tick-borne encephalitis virus (TBEV) and Zika virus
(ZIKV). In more detail, the TBEV-induced host responses in human cells
of neural origin and interferon-mediated protection were described
together with the identification of a new phenomenon of TBEV-induced
host transcriptional and translational shut-off. In addition, virus-derived
molecules with hypothetical immunomodulatory characteristics, TuORF
and ZIKV sfRNA, were analysed for their presence and possible function
during the infection.