| dc.contributor.advisor | Panicucci Zíková, Alena | |
| dc.contributor.author | Lazebnyk, Vladyslav | |
| dc.date.accessioned | 2025-03-06T08:05:37Z | |
| dc.date.available | 2025-03-06T08:05:37Z | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2021-12-15 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/46146 | |
| dc.description.abstract | The catalytic F1-ATP synthase of the human pathogen T. brucei has several unique features. This essential enzyme contains three copies of the novel subunit p18 and it incorporates both subunit peptides generated by a rare proteolytic event. Therefore, we characterized genetic cell lines that deplete the only two known F1-ATP synthase assembly factors in order to gain more insight into the fascinating assembly of this parasitic enzyme. | cze |
| dc.format | 64 | |
| dc.format | 64 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | Trypanosoma brucei | cze |
| dc.subject | parasite | cze |
| dc.subject | ATP-synthase | cze |
| dc.subject | assembly factors | cze |
| dc.subject | p18 | cze |
| dc.subject | Trypanosoma brucei | eng |
| dc.subject | parasite | eng |
| dc.subject | ATP-synthase | eng |
| dc.subject | assembly factors | eng |
| dc.subject | p18 | eng |
| dc.title | Assembly of the unique Trypanosoma brucei F1-ATP synthase | cze |
| dc.title.alternative | Assembly of the unique Trypanosoma brucei F1-ATP synthase | eng |
| dc.type | bakalářská práce | cze |
| dc.identifier.stag | 60043 | |
| dc.description.abstract-translated | The catalytic F1-ATP synthase of the human pathogen T. brucei has several unique features. This essential enzyme contains three copies of the novel subunit p18 and it incorporates both subunit peptides generated by a rare proteolytic event. Therefore, we characterized genetic cell lines that deplete the only two known F1-ATP synthase assembly factors in order to gain more insight into the fascinating assembly of this parasitic enzyme. | eng |
| dc.date.accepted | 2022-01-24 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Biological Chemistry | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Bc. | |
| dc.thesis.degree-program | Biochemistry | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Durante, Ignacio Miguel | |
| dc.description.defence | <ul>
<li>Defence was hybrid, the student was present in person, the members of the commission were present in person or online via MS Teams.</li>
<li>Prof. Grubhoffer welcomed the student and the commission.</li>
<li>The student presented his work „Assembly of the unique <em>Trypanosoma brucei</em> F1-ATP synthase“, introduction to the topic, methods, results and summary.</li>
<li>Supervisor Dr. Zíková presented her review.</li>
<li>Oponnent Dr. Durante presented his review.</li>
<li>Student answered opponent´s questions on identification of ATP11 and ATP12, homology, domains, previous studies, structural alignment, design of RNAi primers, alternative experiments</li>
</ul>
<p> </p>
<p> </p>
<p>5x excellent = excellent</p> | cze |
