| dc.contributor.advisor | Tiemann-Boege, Irene | |
| dc.contributor.author | Moukbel Ali Aldawla, Shehab | |
| dc.date.accessioned | 2025-03-06T08:58:38Z | |
| dc.date.available | 2025-03-06T08:58:38Z | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-10-21 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/46860 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Práce bude přístupná od 25.10.2025 | |
| dc.title | Calling Haplotypes from duplex sequencing data and its application: a case study with Erbb2 data | cze |
| dc.title.alternative | Calling Haplotypes from duplex sequencing data and its application: a case study with Erbb2 data | eng |
| dc.type | bakalářská práce | cze |
| dc.identifier.stag | 70056 | |
| dc.date.accepted | 2022-10-25 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Bioinformatics | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Bc. | |
| dc.thesis.degree-program | Applied Informatics | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.description.defence | <p>1. What are the differences between Repaired and Non-repaired libraries?<br />
2. Do the differences, if any, contribute to the fluctuation of numbers in Repaired and<br />
Non-repaired haplotypes?<br />
3. Does the data quality also influence the haplotype calling? How?<br />
4. Why do we consider the unique counts only?<br />
5. How do we identify the true artifacts from the sequencing errors?<br />
6. What parameters do you use to assess the haplotype/ mutation quality?<br />
7. Do we always apply the same parameters on the data regardless of the library<br />
perpetuation method?<br />
8. Do we consider the distances between the mutations within the haplotype filtration<br />
steps?<br />
9. What are the challenges of finding common haplotypes?<br />
10.How does the comparison to COSMIC & gnomAD contribute to the conclusion?<br />
11.How do we identify if a mutation is a CpG content?<br />
12.What bars represent DNA lesions, and does the tool filter them efficiently? Justify<br />
your answer.</p> | cze |
