| dc.contributor.advisor | Ženka, Jan | |
| dc.contributor.author | Kosenko, Konstantin | |
| dc.date.accessioned | 2026-01-06T11:54:17Z | |
| dc.date.available | 2026-01-06T11:54:17Z | |
| dc.date.issued | 2023 | |
| dc.date.submitted | 2022-12-15 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/48512 | |
| dc.description.abstract | The focus of this thesis was the combination of immunotherapy with glutamine metabolism inhibitors. Glutamine analogs such as 6-diazo-5-oxo-L-norleucine (DON) have been known for many decades; however, their use has been limited due to severe side effects. In this study, we focused on DON and its prodrug LTP607 and tested its combination with immunotherapy that includes mannan-BAM, Toll-like receptor ligands, anti-CD40 antibodies in the rather aggressive pancreatic adenocarcinoma model. The main objective of the study was to compare the side effects of DON and its prodrug, to study the efficiency of this combination against secondary tumors, and to evaluate the influence of such a combination on the survival of mice. | cze |
| dc.format | 59 | |
| dc.format | 59 | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | Cancer immunotherapy | cze |
| dc.subject | glutamine metabolism | cze |
| dc.subject | combination therapy | cze |
| dc.subject | innate immunity | cze |
| dc.subject | adaptive immunity | cze |
| dc.subject | pancreatic adenocarcinoma. | cze |
| dc.subject | Cancer immunotherapy | eng |
| dc.subject | glutamine metabolism | eng |
| dc.subject | combination therapy | eng |
| dc.subject | innate immunity | eng |
| dc.subject | adaptive immunity | eng |
| dc.subject | pancreatic adenocarcinoma. | eng |
| dc.title | Combination of cancer immunotherapy with inhibitors of glutamine metabolism | cze |
| dc.title.alternative | Combination of cancer immunotherapy with inhibitors of glutamine metabolism | eng |
| dc.type | bakalářská práce | cze |
| dc.identifier.stag | 66001 | |
| dc.description.abstract-translated | The focus of this thesis was the combination of immunotherapy with glutamine metabolism inhibitors. Glutamine analogs such as 6-diazo-5-oxo-L-norleucine (DON) have been known for many decades; however, their use has been limited due to severe side effects. In this study, we focused on DON and its prodrug LTP607 and tested its combination with immunotherapy that includes mannan-BAM, Toll-like receptor ligands, anti-CD40 antibodies in the rather aggressive pancreatic adenocarcinoma model. The main objective of the study was to compare the side effects of DON and its prodrug, to study the efficiency of this combination against secondary tumors, and to evaluate the influence of such a combination on the survival of mice. | eng |
| dc.date.accepted | 2023-01-23 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Biological Chemistry | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Bc. | |
| dc.thesis.degree-program | Biological Chemistry | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.description.defence | <p>Prof. Grubhoffer welcome the student. members of the comission, and the audience. Alle members of the commission were present. Mr. Kosenko presented general information about cancer-related death rate, cancer therapy. and specifically about one of the used molecules, DON and its studied derivative. The results for various therapies were shown and discussed. Both the supervisor and the opponent presented their reviews. Then the student answered questions from the audience on the possibilities of the therapy, location of secondary tumours, the used mice, generting of tumours, comparison to standad treatment, etc. the student answered all the questions.</p>
<p>5x excellent = excellent.</p>
<p>The commission suggest this thesis for the Award by the head of the department.</p> | cze |
