| dc.contributor.advisor | Panicucci Zíková, Alena | |
| dc.contributor.author | Ebenstreitová, Julie | |
| dc.date.accessioned | 2026-01-06T11:54:43Z | |
| dc.date.available | 2026-01-06T11:54:43Z | |
| dc.date.issued | 2023 | |
| dc.date.submitted | 2023-04-13 | |
| dc.identifier.uri | https://dspace.jcu.cz/handle/20.500.14390/48587 | |
| dc.description.abstract | Trypanosoma brucei strains that lack their mitochondrial DNA (dyskinetoplastids) are dependent on the reverse activity of the ADP/ATP carrier (AAC) to provide an electrogenic mitochondrial membrane potential (m). Since the intensity of the m and the mitochondrial ATP/ADP ratio dictate the direction of the ADP/ATP carrier, we hypothesize that mitochondrial ATP levels will be kept low in these parasites. Therefore, we analyze the m and parasite viability when we stimulate mitochondrial substrate-level phosphorylation in these dyskinetoplastids. | cze |
| dc.format | 58 s. (124 769 znaků) | |
| dc.format | 58 s. (124 769 znaků) | |
| dc.language.iso | eng | |
| dc.publisher | Jihočeská univerzita | cze |
| dc.rights | Bez omezení | |
| dc.subject | Trypanosoma brucei | cze |
| dc.subject | dyskinetoplastid | cze |
| dc.subject | bioenergetics | cze |
| dc.subject | substrate-level phosphorylation | cze |
| dc.subject | ATP | cze |
| dc.subject | Trypanosoma brucei | eng |
| dc.subject | dyskinetoplastid | eng |
| dc.subject | bioenergetics | eng |
| dc.subject | substrate-level phosphorylation | eng |
| dc.subject | AAC | eng |
| dc.title | The energy metabolism of dyskinetoplastic Trypanosoma parasites | cze |
| dc.title.alternative | The energy metabolism of dyskinetoplastic Trypanosoma parasites | eng |
| dc.type | bakalářská práce | cze |
| dc.identifier.stag | 69854 | |
| dc.description.abstract-translated | Trypanosoma brucei strains that lack their mitochondrial DNA (dyskinetoplastids) are dependent on the reverse activity of the ADP/ATP carrier (AAC) to provide an electrogenic mitochondrial membrane potential (m). Since the intensity of the m and the mitochondrial ATP/ADP ratio dictate the direction of the ADP/ATP carrier, we hypothesize that mitochondrial ATP levels will be kept low in these parasites. Therefore, we analyze the m and parasite viability when we stimulate mitochondrial substrate-level phosphorylation in these dyskinetoplastids. | eng |
| dc.date.accepted | 2023-05-23 | |
| dc.description.department | Přírodovědecká fakulta | cze |
| dc.thesis.degree-discipline | Biologie | cze |
| dc.thesis.degree-grantor | Jihočeská univerzita. Přírodovědecká fakulta | cze |
| dc.thesis.degree-name | Bc. | |
| dc.thesis.degree-program | Biologie | cze |
| dc.description.grade | Dokončená práce s úspěšnou obhajobou | cze |
| dc.contributor.referee | Kovářová, Julie | |
| dc.description.defence | <p>Obhajoba proběhla prezenční formou, v angličtině. Komise: doc. Hassan Hashimi, Ph.D., Mgr. Lenka Chodáková, Ph.D., Mgr. Aleš Horák, Ph.D. Oponent: Mgr. Julie Kovářová, Ph.D.</p>
<p>Průběh obhajoby:</p>
<p>1. Školitelka RNDr. Alena Panicucci Zíková, Ph.D. přečetla svůj posudek.</p>
<p>2. Studentka prezentovala v ca. 20 min svou práci.</p>
<p>3. Oponentka J. Kovářová sumarizovala svoj posudok. Ocenila metódy, ktoré sa študentka v laboratóriu naučila, vytkla len niekoľko formálnych chýb, ktoré sa v práci vyskytli. Oponentka so študentkou následne diskutovala svoje otázky. </p>
<p>4. Diskuze s komisí.</p>
<p>5. Neveřejná část, hlasování pomocí hlas. lístků.</p>
<p>Body: 150</p> | cze |
