Prohlížení Přírodovědecká fakulta dle autora "Panicucci Zíková, Alena"
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Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of <i>Trypanosoma brucei</i> and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
Mittermayr, Martina (Jihočeská univerzita, 2012)The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) ... -
Determining the role of FoF1-ATP synthase dimers in Trypanosoma brucei mitochondrial biogenesis
Hollaus, David (Jihočeská univerzita, 2020)ATP synthase dimers have previously been identified to be major determinants of mitochondrial cristae ultrastructure. In order to determine the role of these dimers in the organellar architecture of Trypanosoma brucei, we ... -
Determining the subcellular compartment in which the unique cleavage of mitochondrial F1 ATPase subunit alpha happens
Andova, Ana-Marija (Jihočeská univerzita, 2020)The T. brucei's infectious stage is characterized by its unique metabolism which requires the mitochondrial FoF1-ATPase to hydrolyze ATP in order to maintain the essential mitochondrial membrane potential. This complex ... -
Druhý homolog eukaryotického inhibičního peptidu F<sub>0</sub>F<sub>1</sub>-ATPázy u <i>Trypanosomy brucei</i>: jeho lokalizace a funkce
Fraňková, Monika (Jihočeská univerzita, 2012) -
Exprese a purifikace mitochondriálních membránových proteinů jednobuněčného parazita <i>Trypanosoma brucei</i> za účelem tvorby protilátek
Urbanová, Simona (Jihočeská univerzita, 2018)Expresné plazmidy génov TbRISP, TbCOXIV a TbNDUFA6 boli vyhotovené molekulárnym klonovaním. Rekombinantné proteíny TbRISP, TbCOXIV a TbNDUFA6 boli exprimované v E. coli, afinitne purifikované a použité k získaniu antiséra ... -
Functional analysis of a putative RNA-editing associated protein 1 (REAP1) in procyclic <i>T. brucei</i>
Čičová, Zdeňka (Jihočeská univerzita, 2007) -
Functional characterization of succinyl-CoA synthetase in the bloodstream form of Trypanosoma brucei
Kubišová, Karolína (Jihočeská univerzita, 2019)During the infectious bloodstream stage (BF), the human pathogen Trypanosoma brucei lacks a canonical cytochrome-mediated respiratory chain. Therefore, this form of the parasite depends on the reverse activity of the ... -
Identifying Protein-Protein Interactions of <i>Trypanosoma brucei</i> F<sub>0</sub>F<sub>1</sub>-ATP Synthase Subunits Using the Yeast Two Hybrid System
Kunzová, Michaela (Jihočeská univerzita, 2016) -
Interactions of Trypanosoma brucei FOF1 ATP Synthase Subunits - An Application of Yeast Two Hybrid
Guggenberger, Matthias (Jihočeská univerzita, 2013)Trypanosoma brucei je jednobuněčný parazit způsobující závažnou spavou nemoc u lidí a nemoc zvanou nagana u zvířat. Tato onemocnění jsou endemická v rozvojových zemí subsaharské Afriky. I když v poslední době klesá počet ... -
Investigating the Regulation of Notch Signalling in <i>Drosophila</i> by Trxr-1 gene
Eder, Andrea (Jihočeská univerzita, 2012)In this work, regulation of Notch signalling by Trxr-1 gene in the Drosophila wing disc was monitored using overexpression constructs or inducing mutant clones in the wing discs. The effect on Notch target gene expression ... -
Localization of the F1-ATP Synthase Subunit alpha and its N' and C' Terminal Fragments in Trypanosoma brucei cells
Lehmayer, Leonie (Jihočeská univerzita, 2018)In this thesis, we explored if the proteolytically excised octapeptide from the Trypanosoma brucei F1-ATP synthase subunit alpha can act as a mitochondrial targeting sequence. Three procyclic 29.13 T. brucei cell lines ... -
Ověření působení fosfanátů acyklických nukleosidů na fosforibozyl transferázy 6-oxo purinů u <i>Trypanosomy brucei</i>
Kotrbová, Zuzana (Jihočeská univerzita, 2012) -
The role of mitochondrial SCoAS substrate-level phosphorylation in the bloodstream form <i>T. brucei</i>
Husová, Michaela (Jihočeská univerzita, 2019)Mitochondrial metabolism of Trypanosoma brucei is considered highly reduced because of its dysfunctional electron transport chain and tricarboxylic acid cycle. But previously published paper suggests significant mitochondrial ...